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Erin Tone

Associate Professor    Member, Clinical Psychology and NBN Programs Joint Appointment: Neuroscience Institute    
Education

Ph.D., Emory University, 2001

Specializations

My research focuses on social cue processing and its role in the emergence and maintenance of anxiety disorders across development. In particular, I use behavioral and neuroimaging (functional magnetic resonance imaging or fMRI) techniques to help elucidate associations between anxiety and the ways in which people respond to social stimuli. I am especially interested in the ways in which social threat cues, such as negative emotional faces or cues of rejection or betrayal, elicit different patterns of behavior and neural activity in the context of anxiety. A core NICHD-funded line of current research in my lab focuses on attention biases for emotional faces; in particular, we are interested in understanding how individual characteristics, such as gender, race/ethnicity, and age, may interact with emotional characteristics (e.g., facial expression) to influence patterns of attention in various anxious or high risk populations, including adults and children with trauma histories and adults with social anxiety. Additional ongoing work examines possible attention bias subtypes among individuals with social anxiety disorder, CBT-related changes in neural activation, and behavioral and neural responses to dynamic, complex, ecologically valid stimuli such as simulated threatening social interactions.

Biography
Publications

Peer-Reviewed Articles 2007-2011

  1. Fani, N., Tone, E.B., Phifer, J., Norrholm, S.B., Bradley, B., Ressler, K.J., Jovanovic, T. (in press). Attention Bias Toward Threat is Associated with Exaggerated Fear Expression and Impaired Extinction in PTSD. Psychological Medicine.
  2. Lau, J.Y.F., Guyer, A.E., Tone, E. B., Jenness, J., Parrish, J.M., Pine, D.S., & Nelson, E.E. (in press). Amygdala Responses to Social Rejection in Anxious Adolescents. International Journal of Behavioral Development.
  3. Tone, E. B., Goodfellow, S., Nowicki, S. Jr. (in press). Father Locus of Control and Child Emotional and Behavioral Outcomes: A Prospective Study. Journal of Genetic Psychology.
  4. Fani, N., Bradley, B., Ressler, K., & McClure-Tone, E. B. (2011). Attention Bias in Adult Survivors of Childhood Maltreatment with and without Posttraumatic Stress Disorder. Cognitive Therapy and Research, 35, 57-67.
  5. McClure-Tone, E. B. (2011). Introduction to the special issue on typical and atypical neural processing of emotional and social cues across the lifespan. Developmental Neuropsychology, 36(4), 405-407.
  6. McClure-Tone, E. B., Nawa, N. E., Nelson, E. E., Detloff, A. M., Fromm, S., Pine, D. S., & Ernst, M. (2011). Preliminary Findings: Neural Responses to Feedback Regarding Betrayal and Cooperation in Adolescent Anxiety Disorders.Developmental Neuropsychology, 36(4), 453-472.
  7. Price, M., Mehta, N., Tone, E. B., Anderson, P. L. (2011). Does engagement with exposure yield better outcomes?: Components of presence as a predictor of treatment response for virtual reality exposure therapy for social phobia. Journal of Anxiety Disorders, 25, 763-770. doi: 10.1016/j.janxdis.2011.03.004
  8. Price, M., Tone, E. B., & Anderson, P. L. (2011). Vigilant and avoidant attention biases as predictors of response to cognitive behavioral therapy for social phobia. Depression and Anxiety, 28, 349-353. doi: 10.1002/da.20791
  9. Somerville, L. H., Fani, N., & McClure-Tone, E. B. (2011). Neural processing of emotional and social cues across the lifespan. Developmental Neuropsychology, 36(4), 408-428.
  10. Tone, E. B., Goulding, S. M., & Compton, M. T. (2011). Associations among perceptual anomalies, social anxiety, and paranoia in a college student sample. Psychiatry Research, 188, 258-263.
  11. Maslowsky, J., Mogg, K., Bradley, B.P., McClure-Tone, E. B., Ernst, M., Pine, D.S., Monk, C.S. (2010). A preliminary investigation of neural correlates of treatment in adolescents with Generalized Anxiety Disorder. Journal of Child and Adolescent Psychopharmacology, 20, 105-111.
  12. Beesdo, K., Lau, J., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., Fromm, S. J., Goldwin, M.A., Wittchen, H-U., Leibenluft, E., Ernst, M., & Pine, D. S. (2009). Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Archives of General Psychiatry, 66, 275-285.
  13. Compton, M. T., Goulding, S. M., Bakeman, R., & McClure-Tone, E. B. (2009a). Confirmation of a Four-Factor Structure of the Schizotypal Personality Questionnaire in Non-Psychiatric Young Adults. Schizophrenia Research, 111, 46-52.
  14. Compton, M. T., Goulding, S. M., Bakeman, R., & McClure-Tone, E. B. (2009b). Measuring Schizotypy: Psychometric Properties and Factorial Structure of Three Self-Report Rating Scales in Non-Psychiatric Young Adults.Schizophrenia Research, 115, 286-289.
  15. Esterberg, M. L., Goulding, S. M., McClure-Tone, E. B., & Compton, M. T. (2009). Schizotypy and Nicotine, Alcohol, and Cannabis Use in a Non-Psychiatric Sample. Journal of Addictive Behaviors, 34, 374-379.
  16. Goulding, S. M., McClure-Tone, E. B., & Compton, M. T. (2009). Associations between multiple dimensions of schizotypy and sociodemographic variables in a non-psychiatric sample of young adults. Journal of Nervous and Mental Disease, 197, 786-789.
  17. Guyer, A. E., McClure-Tone, E. B., Shiffrin, N. D., Pine, D. S., & Nelson, E. E. (2009). Probing the Neural Correlates of Anticipated Peer Evaluation in Adolescence.  Child Development, 80, 1000-1015.
  18. McClure-Tone, E. B. (2009). Socio-emotional functioning in bipolar disorder versus typical development: Behavioral and neural differences.Clinical Psychology: Science and Practice, 16,98-113.
  19. Guyer, A. E., Lau, J. Y. F., McClure-Tone, E. B., Parrish, J., Shiffrin, N. D., Blair, R. J. R., Leibenluft, E., Fox, N. A., Ernst, M., Pine, D. S., & Nelson, E. E. (2008). Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Archives of General Psychiatry, 65, 1303-1312.
  20. Guyer, A. E., Monk, C. S., McClure-Tone, E. B., Nelson, E. E., Roberson-Nay, R., Adler, A. D., Fromm, S., Leibenluft, E., Pine, D. S., & Ernst, M. (2008). A developmental examination of amygdala response to facial expressions. Journal of Cognitive Neuroscience, 20, 1565-1582.
  21. Masten, C.L., Guyer, A.E., Hodgdon, H.B., McClure, E.B., Charney, D.S., Ernst, M., Kaufman, J., Pine, D.S., & Monk, C.S. (2008). Recognition of facial emotions among maltreated children with high rates of post–traumatic stress disorder. Child Abuse & Neglect, 32, 139-153.
  22. Monk, C.S., Klein, R.G., Telzer, E.H., Schroth, E.A., Mannuzza, S., Moulton, J.L., Guardino, M., Masten, C.L., McClure-Tone, E.B., Fromm, S., Blair, R.J.R., Pine, D.S., Ernst, M. (2008). Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression.American Journal of Psychiatry, 165, 90-98.
  23. Monk, C.S., Telzer, E.H., Mogg, K., Bradley, B. P., Xiaoqin, M., McClure-Tone, E.B., Ernst, M., & Pine, D.S., (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Archives of General Psychiatry,65, 568-576.
  24. Roy, A. L., Vasa, R. A., Bruck, M., Mogg, K., Bradley, B. P., Sweeney, M.; Bergman, L., McClure-Tone, E. B., Pine, D. S., The CAMS Team (2008). Attentional bias toward threat in pediatric anxiety disorders. Journal of theAmerican Academy of Child and Adolescent Psychiatry, 47, 1189-1196.
  25. Dickstein, D. P., Nelson, E. E., McClure, E. B., Grimley, M. E., Knopf, L., Brotman, M. A., Rich, B. A., Pine, D. S., Leibenluft, E. (2007).  Cognitive flexibility in phenotypes of pediatric bipolar disorder.  Journal of the American Academy of Child and Adolescent Psychiatry, 46, 341-355.
  26. Guyer, A.E., McClure, E.B., Adler, A.D., Brotman, M.A., Rich, B.A., Kimes, A.S., Pine, D.S, Ernst, M., & Leibenluft, E. (2007). Specificity of facial expression labeling deficits in childhood psychopathology. Journal of Child Psychology and Psychiatry, 48, 863-871.
  27. Leibenluft, E., Rich, B.A., Vinton, D.T., Nelson, E.E., Fromm, S.J., Berghorst, L.H., Joshi, P., Robb, A., Schachar, R.J., Dickstein, D.P., McClure, E.B., & Pine, D.S. (2007). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. American Journal of Psychiatry, 164, 52-60.
  28. McClure, E.B., Adler, A., Monk, C.S., Cameron, J., Smith, S., Nelson, E.E., Leibenluft, E., Ernst, M., & Pine, D.S. (2007). fMRI predictors of treatment outcome in pediatric Generalized Anxiety Disorder. Psychopharmacology, 191, 97-105.
  29. McClure, E.B., Monk, C.S., Nelson, E.E., Parrish, J.M., Adler, A., Blair, R.J.R., Fromm, S.J., Charney, D.S., Leibenluft, E., Ernst, M., & Pine, D.S. (2007). Abnormal attention modulation of fear circuit activation in pediatric Generalized Anxiety Disorder. Archives of General Psychiatry, 64, 94-106.
  30. McClure, E.B., Parrish, J.M., Nelson, E.E., Easter, J., Thorne, J.F., Rilling, J.K., Ernst, M. & Pine, D.S. (2007). Responses to conflict and cooperation in adolescents with anxiety and mood disorders.Journal of Abnormal Child Psychology, 35, 567-577.
  31. Pérez-Edgar, K., Roberson-Nay, R., Hardin, M.G., Poeth, K., Guyer, A.,  Nelson, E. E., McClure, E. B., Henderson, H., Fox, N. A., Pine, D.S., & Ernst, M. (2007). Attention Alters Neural Responses to Evocative Faces in Behaviorally Inhibited Adolescents. Neuroimage, 35, 1538-1546.

Selected Peer-Reviewed Publications (pre-2007)

  1. Monk, C.S., Nelson, E.E., McClure, E.B., Mogg, K., Bradley, B.P., Leibenluft, E., Blair, R.J.R., Chen, G., Charney, D.S., Ernst, M., Pine, D.S. (2006). Ventrolateral prefrontal cortex activation and attention bias in response to angry faces in adolescents with generalized anxiety disorder.American Journal of Psychiatry, 163, 1091-1097.
  2. Rich, B.A., Vinton, D.T., Roberson-Nay, R., Hommer, R.E., Berghorst, L.H., McClure, E.B., Fromm, S.J., Pine, D.S., Leibenluft, E. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder.  Proceedings of the National Academyof Science, 103, 8900-8905.
  3. McClure, E. B., Treland, J.E., Snow, J., Dickstein, D.P., Towbin, K.E., Charney, D.S., Pine, D. S., & Leibenluft, E. (2005). Memory and learning deficits in pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 461-469.
  4. Ernst, M., Jazbec, S., McClure, E.B., Monk, C. S., Blair, R.J.R., Leibenluft, E., & Pine, D.S. (2005). Amygdala and nucleus accumbens activation in response to receipt and omission of gains in adults and adolescents. Neuroimage, 25, 1279-1291.
  5. Pine, D. S., Mogg, K., Bradley, B., Montgomery, L. A., Monk, C., McClure, E., Schweder, A., Ernst, M., Charney, D. S., & Kaufman, J. (2005). Attention bias to threat in maltreated children: Implications for vulnerability to stress-related psychopathology. American Journal of Psychiatry, 162, 291-296.
  6. Nelson, E.E., Leibenluft, E., McClure, E.B., & Pine, D.S. (2005). The social reorientations of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, 1-12.
  7. Monk, C.S., Nelson, E.E., Woldehawariat, G., Montgomery, L.A., Zarahn, E., McClure, E.B., Guyer, A.E., Leibenluft, E., Charney, D.S., Ernst, M., & Pine, D.S. (2004). Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans. Biological Psychiatry, 56, 607-610.
  8. Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., Charney, D., & Pine, D. S. (2004). Choice selection and reward anticipation: An fMRI study.  Neuropsychologia, 42, 1585-1597.
  9. McClure, E. B., Monk, C. S., Nelson, E. E., Zarahn, E., Leibenluft, E., Bilder, R. M., Charney, D. S., Ernst, M., & Pine, D. S. (2004). A developmental examination of gender differences in brain engagement during evaluation of threat. Biological Psychiatry, 55, 1047-1055.
  10. Dickstein D. P., Treland J. E., Snow J, McClure E. B., Mehta M. S., Towbin K. E., Pine D. S., Leibenluft E. (2004). Neuropsychological performance in pediatric bipolar disorder.  Biological Psychiatry, 55, 32-39.
  11. Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E., Charney, D. S., Ernst, M., & Pine, D. S. (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions.  NeuroImage, 20, 420-428.
  12. Nelson, E. E., McClure, E. B., Monk, C. S., Zarahn, E., Leibenluft, E., Pine, D. S., & Ernst, M. (2003).  Developmental differences in neuronal engagement during implicit encoding of emotional faces: An event-related fMRI study.  Journal of Child Psychology, Psychiatry and Allied Disciplines, 44, 1015-1024.
  13. McClure, E. B., Pope, K., Hoberman, A. J., Pine, D. S., & Leibenluft, E. (2003). Facial expression recognition in adolescents with mood and anxiety disorders. American Journal of Psychiatry, 160 , 1172-1174.
  14. McClure, E. B., Kubiszyn, T., & Kaslow, N. J. (2002). Advances in the diagnosis and treatment of childhood mood disorders. Professional Psychology: Research and Practice, 33, 125-134.
  15. McClure, E. B., & Nowicki, S., Jr. (2001).  Associations between social anxiety and nonverbal processing skill in preadolescent boys and girls.  Journal of Nonverbal Behavior, 25, 3-19.
  16. McClure, E. B., Brennan, P., Hammen, C., & LeBrocque, R. (2001).  Perceived parenting behavior as a mediator of the relationship between parent and child anxiety disorders in a high-risk sample.  Journal of Abnormal Child Psychology, 29, 1-10.
  17. McClure, E. B. (2000). A meta-analytic review of sex differences in facial expression processing and their development in infants, children, and adolescents.  Psychological Bulletin, 126, 424-453.